The Center for Women’s Mental Health at Massachusetts General Hospital provides state-of-the-art evaluation and treatment of psychiatric disorders associated with female reproductive function including premenstrual dysphoric disorder (PMDD), pregnancy-associated mood disturbance, postpartum psychiatric illness, and peri- and post- menopausal depression. Clinical care is complemented by research in each of these areas ranging from studies of a spectrum of treatments for women who suffer from PMDD, postpartum depression, and depression in menopause to longitudinal observational studies for women who suffer from mood disorders during pregnancy.