Category Archives: Hormonal Therapy

Hormone Replacement Therapy Revisited

Hormone Replacement Therapy Revisited

As a result of dramatically increased life expectancies in industrialized countries, healthy women today expect to spend nearly 40% of their lives after menopause. For these postmenopausal women, lack of estrogen may contribute to long-term adverse effects, including cardiovascular disease and osteoporosis. Many postmenopausal women might benefit from hormone replacement therapy (HRT) with estrogens [...]

Oral Contraceptives for the Treatment of Premenstrual Mood Symptoms

Oral Contraceptives for the Treatment of Premenstrual Mood Symptoms

Oral contraceptives are commonly prescribed for the treatment of premenstrual symptoms and premenstrual dysphoric disorder (PMDD); however, the evidence supporting the use of oral contraceptives in this setting is limited. While most studies have shown that oral contraceptives are not effective for the treatment of premenstrual symptoms, there is preliminary evidence that a new [...]

Paroxetine CR May Be Helpful for Menopausal Women Discontinuing Hormone Therapy

Paroxetine CR May Be Helpful for Menopausal Women Discontinuing Hormone Therapy

Estrogen was first approved by the FDA for the treatment of menopausal symptoms in 1942, and for many decades estrogen replacement therapy had been widely prescribed for peri- and post-menopausal women. In 2002, however, data from the Women’s Health Initiative (WHI) suggested that hormonal therapy may be associated with an increased risk of breast [...]

Can Estrogen Be Used to Treat Posptartum Depression?

Can Estrogen Be Used to Treat Posptartum Depression?

After delivery, women experience a dramatic drop in estrogen hormone levels. Many have hypothesized that this decline in estrogen levels may precipitate postpartum depression (PPD) in susceptible individuals, and several studies have explored the use of estrogen for the treatment of depression after delivery.
In a double blind, placebo-controlled study including 61 women with PPD, [...]

Does Estrogen Improve Cognition?

Does Estrogen Improve Cognition?

While earlier observational studies suggested that postmenopausal hormone treatment may improve cognitive functioning in women, studies from the Women’s Health Initiative have shown that estrogen replacement therapy started in postmenopausal women (65 years or older) did not enhance cognitive functioning nor did it decrease the risk of dementia.
In order to assess the effect of [...]

Two MGH Center for Women’s Mental Health Physicians Featured in Elle Magazine

Two MGH Center for Women’s Mental Health Physicians Featured in Elle Magazine

Lee S. Cohen, MD, and Hadine Joffe, MD, MSc, shared their expertise in reproductive health and oral contraceptives (OC) for Elle magazine’s recent article, “Against the Flow.” The article discusses Lybrel, the first continuous OC approved by the Food and Drug Administration (FDA). This new birth control pill has received attention because its continual low [...]

Perimenopause: A Time of Risk for Depression

Perimenopause: A Time of Risk for Depression

More than 50 percent of women experience some perimenopausal symptoms, including hot flushes, night sweats, and sleep disturbance, before reaching the menopause. A recent article from Aetna Intelihealth notes that many women may also experience depression. In a study form Dr. Claudio Soares, women with clinically confirmed perimenopause were interviewed:
Of the 101 women studied, nearly [...]