Comments on: Interactions Between Antidepressants and Tamoxifen http://www.womensmentalhealth.org/posts/interactions-between-antidepressants-and-tamoxifen/ MGH Center for Women's Mental Health Wed, 13 Jan 2010 19:16:50 +0000 http://wordpress.org/?v=abc hourly 1 By: Edna Spohn http://www.womensmentalhealth.org/posts/interactions-between-antidepressants-and-tamoxifen/comment-page-1/#comment-23744 Edna Spohn Thu, 17 Dec 2009 23:06:45 +0000 http://www.womensmentalhealth.org/?p=344#comment-23744 This article is excellent advice. I am taking Tamoxifen and had just been prescribed Lexapro ---- the generic version. I did not pick it up at the pharmacy, but brought these articles out to show him that I didn't think I should be taking that medicine. Now is there some risk of taking venlafaxine which is a weak inhibitor which I had been prescribed,but it interfers with my night time sleeping? I initially spotted this information in the Fall issue of the CURE magazine This article is excellent advice. I am taking Tamoxifen and had just been prescribed Lexapro —- the generic version.
I did not pick it up at the pharmacy, but brought these articles out to show him that I didn’t think I should be taking that medicine.
Now is there some risk of taking venlafaxine which is a weak inhibitor which I had been prescribed,but it interfers with my night time sleeping?
I initially spotted this information in the Fall issue of the CURE magazine

]]> By: MGH Center for Women's Mental Health http://www.womensmentalhealth.org/posts/interactions-between-antidepressants-and-tamoxifen/comment-page-1/#comment-21450 MGH Center for Women's Mental Health Fri, 13 Nov 2009 16:36:23 +0000 http://www.womensmentalhealth.org/?p=344#comment-21450 This is a very interesting observation. While there is no specific name to describe what you have observed, there do seem to be certain women who are more vulnerable to mood changes during hormonal transitions. For example, we sometimes see women with histories of postpartum depression who develop recurrent symptoms during the menopausal transition. There is not too much research on this topic. <a href="http://www.ncbi.nlm.nih.gov/pubmed/10831472" rel="nofollow">Bloch and colleagues </a>observed that in women with histories of postpartum depression, a similar episode of depression could be elicited by abruptly withdrawal of estrogen. Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. Effects of gonadal steroids in women with a history of postpartum depression. <em>Am J Psychiatry</em>. 2000 Jun;157(6):924-30. This is a very interesting observation. While there is no specific name to describe what you have observed, there do seem to be certain women who are more vulnerable to mood changes during hormonal transitions. For example, we sometimes see women with histories of postpartum depression who develop recurrent symptoms during the menopausal transition.

There is not too much research on this topic. Bloch and colleagues observed that in women with histories of postpartum depression, a similar episode of depression could be elicited by abruptly withdrawal of estrogen.

Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry. 2000 Jun;157(6):924-30.

]]> By: Ruth Steinman, MD http://www.womensmentalhealth.org/posts/interactions-between-antidepressants-and-tamoxifen/comment-page-1/#comment-21157 Ruth Steinman, MD Fri, 06 Nov 2009 13:20:27 +0000 http://www.womensmentalhealth.org/?p=344#comment-21157 I have a 38 year old patient with a history of post-partum depression who one month into Tamoxifen treatment developed a severe agitated depression with suicidal ideation. She describes a history of mood changes with BCP use in her twenties. She is high risk for recurrence of breast cancer and her cancer is highly estrogen sensitive, so a decision not to treat with Tamoxifen is a difficult one for her. I had a recent patient who developed a similar agitated depression during pregnancy. I am wondering if there is a name for this-women who have a CNS extremely vulnerable to hormonal changes who develop an extreme level of agitation. I have a 38 year old patient with a history of post-partum depression who one month into Tamoxifen treatment developed a severe agitated depression with suicidal ideation. She describes a history of mood changes with BCP use in her twenties. She is high risk for recurrence of breast cancer and her cancer is highly estrogen sensitive, so a decision not to treat with Tamoxifen is a difficult one for her.

I had a recent patient who developed a similar agitated depression during pregnancy.

I am wondering if there is a name for this-women who have a CNS extremely vulnerable to hormonal changes who develop an extreme level of agitation.

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